Sequencing.com is a profitable, Series A company at the intersection of biotech, genomics, and personalized health. As the world’s largest direct-to-consumer genomics platform, our mission is to power the future of personalized health by making whole genome sequencing and interpretation accessible, actionable, and meaningful for everyone. We partner with healthcare professionals, research organizations, and consumer wellness platforms to deliver deep genomic insights through our advanced data and bioinformatics platform. We are venture-backed, rapidly scaling, and assembling a team that is excited to build products that change the world.

The Position

At Sequencing, you'll build and operate the evaluation and validation infrastructure that keeps our AI systems correct, reliable, and regression-protected. This is an execution-focused role: you'll design, implement, and maintain the benchmarking systems that continuously test AI outputs against curated genomic datasets, partnering closely with the AI Bioinformatics Engineering Lead to turn interpretation standards into measurable, operational systems. You are detail-oriented, have a systems-thinking mindset and you notice the one VCF out of ten thousand that doesn't look right

The Impact

Build and run automated evaluation pipelines for AI outputs end-to-end.
Expand regression datasets that cover variant normalization, transcript ambiguity, and disease-level mapping.
Execute large-scale validation runs across curated VCF datasets, track performance over time, and surface accuracy regressions the moment they appear.
Grow a structured question bank using DV3 and related datasets, encoding the edge cases that matter most.
Maintain ground truth datasets for pathogenic and benign variants so our benchmarks reflect real-world genomic complexity.
Ship automated regression tests for every AI release and build dashboards that make variant-level and case-level accuracy visible to the whole team.
Partner with engineering to wire validation directly into CI/CD, and diagnose and document failure modes as they emerge.

Dominant and Expressed Traits

Degree in Bioinformatics, Computational Biology, Genetics, or a related field.
Deep, hands-on experience with VCFs and real-world genomic datasets.
Fluency with ClinVar, dbSNP, HGVS standards, and transcript mapping.
A track record building evaluation frameworks or testing pipelines, Langfuse or similar.
Experience evaluating LLM-based systems and standing up automated QA at scale.
Comfort living inside modern data engineering workflows.

Benefits Overview

We offer a comprehensive benefits package, including:

Health, Vision, and Dental, Life Insurance
401(k) with Company Matching
Fully Remote Work
Paid Time Off
Volunteer Time Off (paid time off for volunteering at non-profit or equivalent)
Parental Bonding Time
Short-Term Disability Insurance
Remote Work Reimbursements (equipment, cellular, wifi, office supplies, etc.)
Weekly paydays (every Friday)
Genome sequencing for you and your immediate family (private and confidential)

Sequencing Inc. is an equal opportunity employer. All aspects of employment, including the decision to hire, promote, discipline, or discharge, will be based on merit, competence, performance, and business needs. We do not discriminate based on race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law.

Sequencing Inc. may use artificial intelligence (AI) or automated tools as part of the recruiting and hiring process, including for application screening and candidate evaluation. These tools may analyze information provided in your application materials or during the hiring process. Where required by applicable law, candidates may request a reasonable accommodation or an alternative selection process by contacting joinus@sequencing.com.

AI Bioinformatics Benchmarking Engineer