Our mission is to detect cancer early, when it can be cured. We are working to change the trajectory of cancer mortality and bring stakeholders together to adopt innovative, safe, and effective technologies that can transform cancer care.

We are a healthcare company, pioneering new technologies to advance early cancer detection. We have built a multi-disciplinary organization of scientists, engineers, and physicians and we are using the power of next-generation sequencing (NGS), population-scale clinical studies, and state-of-the-art computer science and data science to overcome one of medicine’s greatest challenges.

GRAIL is headquartered in the bay area of California, with locations in Washington, D.C., North Carolina, and the United Kingdom. It is supported by leading global investors and pharmaceutical, technology, and healthcare companies.

For more information, please visit grail.com

Our mission is to detect cancer early, when it can be cured. We are working to change the trajectory of cancer mortality and bring stakeholders together to adopt innovative, safe, and effective technologies that can transform cancer care.

We are a healthcare company, pioneering new technologies to advance early cancer detection. We have built a multi-disciplinary organization of scientists, engineers, and physicians and we are using the power of next-generation sequencing (NGS), population-scale clinical studies, and state-of-the-art computer science and data science to overcome one of medicine’s greatest challenges.

GRAIL is headquartered in the bay area of California, with locations in Washington, D.C., North Carolina, and the United Kingdom. It is supported by leading global investors and pharmaceutical, technology, and healthcare companies.

For more information, please visit grail.com

The Equipment Engineer 2 provides professional engineering support in the evaluation, installation, optimization, and maintenance of manufacturing equipment and automation systems. Operating with increasing independence, this role applies engineering principles to analyze equipment performance, resolve technical issues, and contribute to improvements that enhance reliability, efficiency, and compliance. The position partners with cross-functional teams to implement engineering solutions, maintain accurate technical documentation, and ensure equipment systems operate effectively within defined standards and operational goals.

You will work on-site full-time at our office located in Durham, NC

The Equipment Engineer 2 provides professional engineering support in the evaluation, installation, optimization, and maintenance of manufacturing equipment and automation systems. Operating with increasing independence, this role applies engineering principles to analyze equipment performance, resolve technical issues, and contribute to improvements that enhance reliability, efficiency, and compliance. The position partners with cross-functional teams to implement engineering solutions, maintain accurate technical documentation, and ensure equipment systems operate effectively within defined standards and operational goals.

You will work on-site full-time at our office located in Durham, NC

Responsibilities:

Conducts professional engineering analyses to assess equipment performance, identify reliability concerns, and develop data-driven recommendations for improvement.
Supports the installation, modification, and qualification of laboratory manufacturing equipment by applying engineering principles and collaborating with technicians, engineers, and operations teams.
Executes advanced maintenance, repair, and technical adjustments on complex manufacturing equipment by applying extensive procedural knowledge and hands-on expertise
Applies structured problem-solving methods to troubleshoot equipment issues, develop corrective actions, and implement improvements that strengthen equipment reliability.
Develops, updates, and maintains engineering documentation, including technical specifications, process instructions, test results, and change records, in accordance with engineering controls.
Collaborates with cross-functional partners on continuous improvement initiatives, contributing engineering insights that enhance equipment capability, throughput, and performance.
Supports preventive and predictive maintenance programs by evaluating equipment behavior, reviewing failure data, and recommending engineering-driven reliability enhancements.
Performs engineering-level testing, calibration, and verification activities to ensure equipment accuracy and compliance with quality and safety standards.
Exercises professional judgment within established engineering practices to ensure safe, compliant, and efficient operation of manufacturing equipment.
These responsibilities summarize the role’s primary responsibilities and are not an exhaustive list. They may change at the company’s discretion.

Required Qualifications:

Bachelor’s degree in mechanical engineering, electrical engineering, manufacturing engineering, or related discipline.
2 + years of relevant experience in equipment engineering, manufacturing, or maintenance engineering, or a master’s degree with 0–2 years of experience.
Demonstrated knowledge of automated manufacturing systems, control systems, and process instrumentation.
Proficiency in reading and interpreting mechanical and electrical drawings and schematics.
Familiarity with root cause analysis and failure mode and effects analysis (FMEA) tools.
Demonstrated level of knowledge regarding applicable regulatory standards commensurate with the position's complexity and scope, contributing to organizational regulatory compliance. Minimal applicable standards for this position include:
GMP quality management systems (e.g. ISO 13485)
Clinical laboratory regulations (e.g. CAP, CLIA, NYSDOH, ISO 15189)
Operations within the regulated medical device environment (e.g. IVDD, IVDR, FDA 21 CFR 800 series, FDA 21 CFR Part 11)

Preferred Qualifications:

Strong problem-solving skills with the ability to diagnose complex equipment and process issues.
Analytical and data-driven approach to process improvement and decision-making.
Effective collaboration and communication skills across technical and operational teams.
Ability to manage multiple assignments and adapt to changing priorities in a fast-paced environment.
Commitment to quality, safety, and operational excellence.

Physical Demands and Work Environment

Works in a manufacturing and engineering environment with frequent exposure to production equipment, machinery, and moderate noise.
May require hands-on support in production areas, including standing, bending, or lifting equipment components.
Use of personal protective equipment (PPE) is required per safety and compliance standards.
May occasionally require overtime or off-shift support to address critical maintenance or project activities.

The expected, full-time, annual base pay scale for this position is $82,000 - $102,000 . Actual base pay will consider skills, experience, and location.

This role may be eligible for other forms of compensation, including an annual bonus and/or incentives, subject to the terms of the applicable plans and Company discretion. This range reflects a good-faith estimate of the range that the Company reasonably expects to pay for the position upon hire; the actual compensation offered may vary depending on factors such as the candidate’s qualifications. Employees in this role are also eligible for GRAIL’s comprehensive and competitive benefits package, offered in accordance with our applicable plans and policies. This package currently includes flexible time-off or vacation; a 401(k) retirement plan with employer match; medical, dental, and vision coverage; and carefully selected mindfulness programs.

GRAIL is an equal employment opportunity employer, and we are committed to building a workplace where every individual can thrive, contribute, and grow. All qualified applicants will receive consideration for employment without regard to race, color, religion, national origin, sex, gender, gender identity, sexual orientation, age, disability, status as a protected veteran, , or any other class or characteristic protected by applicable federal, state, and local laws. Additionally, GRAIL will consider for employment qualified applicants with arrest and conviction records in a manner consistent with applicable law and provide reasonable accommodations to qualified individuals with disabilities. Please contact us at rc@grailbio.com if you require an accommodation to apply for an open position.

GRAIL maintains a drug-free workplace. We welcome job-seekers from all backgrounds to join us!

Equipment Engineer 2 #4778, #4779 (Night Shift 10:00pm - 8:00am, Tue - Fri)